Professional & One-stop Lentivirus Packaging Solutions

The lentivirus vector, which is derived from HIV-1 and engineered to contain the vesicular stomatitis virus glycoprotein (VSVG) envelope, represents a highly powerful gene therapy vector. As a modified retrovirus, its virulence genes have been replaced with an exogenous target gene. This novel design empowers the vector to integrate the exogenous gene efficiently into the host chromosome, thus enabling stable and long-lasting expression of the introduced gene.

Furthermore, the lentivirus vector demonstrates versatile infection capabilities, effectively targeting a wide array of cell types. These include neurons, hepatocytes, cardiomyocytes, tumor cells, endothelial cells, stem cells, and many others. This broad tropism ensures robust and reliable gene transduction, rendering the lentivirus vector an indispensable tool for advanced gene therapy applications. LifeSct offers a one-stop service, covering everything from gene synthesis to lentivirus packaging. It provides high-quality lentiviral packaging plasmids that are suitable for both cell infection and in vivo animal experiments.

Key Features

• Broad Infection Spectrum: The lentivirus vector can efficiently infect both dividing and non - dividing cells, including primary cells.
• Stable Expression: Once it infects the host cell, the lentivirus integrates the exogenous gene into the host cell's genome. This allows for continuous and stable expression throughout cell division..
• High Safety Profile: The lentivirus is a recombinant replication - defective strain. This ensures operational safety since it cannot replicate autonomously.
• Resistance to Gene Silencing: The integrated exogenous gene fragments are resistant to gene silencing.
• Large Payload Capacity: It is capable of carrying relatively large exogenous fragments, with a capacity of up to 4.8 kb.
 

Selection Guide

* Download the list of lentiviral packaging plasmids;
** Turnaround time includes plasmid construction and preparation.

Deliverables