Human Adenovirus Type5 (dE1/E3) expressing Synuclein, Alpha (non A4 Component Of Amyloid Precursor) (SNCA) under a CMV promoter.
Description:
Synuclein, Alpha (non A4 Component Of Amyloid Precursor), pre-packaged adenovirus, ready to ship and ready to use format.
Gene Name:
Synuclein, Alpha (non A4 Component Of Amyloid Precursor)
ACCN:
BC013293
Gene ID:
6622
GI Number:
15342041
Fusion Tag:
No
Promoter:
CMV
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
